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Openai/6957e12e-1688-8008-b9b0-ff87c1b2d7bb
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=== Assistant: Good question — and this is where precision matters. === Good question — and this is where precision matters. ===== No. Right now you should ''not'' split the same dose between sublingual and oral. ===== Doing half sublingual + half oral is more destabilizing, not gentler, in your current state. Let me explain exactly why. ==== Each route has different pharmacokinetics: ==== ===== - Rapid absorption ===== * Sharp E2 peak (within ~30–60 min) * Short half-life * Strong CNS signaling ===== - Slow absorption ===== * Lower peak E2 * Higher E1 formation * Smoother curve If you split: * You get a fast spike + a slow tail * The brain experiences two signals, not one * In a sensitized nervous system, this can: - Worsen anxiety - Trigger insomnia - Increase “wired but tired” feelings Endocrinology guidance favors one route at a time when stabilizing. ==== Given: ==== * T ~1000 * Severe insomnia * Recent HRT stop/start * Autonomic hyperarousal Your system needs: * Predictability * Single daily curve * No peaks Mixing routes defeats that. ==== If the tablet is scored: ==== * 0.5 mg oral swallowed once daily (cut tablet, swallow whole with water) That’s dose reduction — not route splitting. ==== Only after: ==== * Sleep stabilizes * Anxiety settles * You’ve been on a steady dose ≥2 weeks Even then, it’s usually better to switch routes, not combine them. ==== - Splitting dose = okay ==== * Splitting route = destabilizing right now Right now your goal is calm, boring hormones. If you want, tell me: * What tablet strength you have (1 mg? 2 mg?) * Whether it’s scored I’ll help you choose the least activating way to take it tonight or tomorrow.
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