Editing Openai/69101fc6-f990-800a-9638-7716259af6c4 (section)

=== - LDL-C ↓ ~15–34% (often ~30–40 mg/dL) in 8–16 weeks; ApoB and non-HDL-C ↓ similarly Measure: lipid panel + ApoB Why: RYR’s monacolin K inhibits HMG-CoA reductase (statin-like). Effect size depends on monacolin content (varies by brand). MDPI<ref>{{cite web|title=MDPI|url=https://www.mdpi.com/2072-6643/15/10/2288|publisher=mdpi.com|access-date=2025-11-09}}</ref>PMC<ref>{{cite web|title=PMC|url=https://pmc.ncbi.nlm.nih.gov/articles/PMC6822657/|publisher=pmc.ncbi.nlm.nih.gov|access-date=2025-11-09}}</ref>Frontiers<ref>{{cite web|title=Frontiers|url=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.819482/full|publisher=frontiersin.org|access-date=2025-11-09}}</ref> ===
* Blood pressure: small additional ↓ reported in some trials; garlic may contribute modest BP and LDL reductions Measure: home BP; lipid panel Why: garlic’s organosulfur compounds can improve NO and mildly affect lipids/BP. (Garlic meta-analyses; not cited above to save space.)
* Safety monitoring (very important): check ALT/AST and CK at baseline and ~8–12 weeks; avoid concurrent statins unless supervised; U.S. products with pharmacologic monacolin K are regulated like drugs. (Regulatory/safety consensus; RYR review discusses this.) PMC<ref>{{cite web|title=PMC|url=https://pmc.ncbi.nlm.nih.gov/articles/PMC6822657/|publisher=pmc.ncbi.nlm.nih.gov|access-date=2025-11-09}}</ref>

==== - Bloods (day 0 & 90): lipid panel + ApoB, hs-CRP, HbA1c, CMP (liver/kidney), homocysteine (if on B-vitamins), CoQ10 (if on ubiquinol), dp-ucMGP (if on K2), RBC/whole-blood GSH (if on NAC/GSH). ====
* Vitals/devices: home BP averages; CGM for 2 weeks at baseline and again at week 12 to quantify post-shake glycemic response; grip strength; DXA for lean mass (if using creatine/protein); skin measurements (derm clinic) for collagen/HA; vascular FMD if you want to detect endothelial changes.
* Expected “most visible” movers by 90 d: LDL-C/ApoB with RYR; dp-ucMGP with K2; MPOD with lutein/zeaxanthin; hs-CRP (small) with curcumin; PBMC NAD+ with NR; GSH with NAC/GSH; post-prandial glucose iAUC with isomaltulose/allulose/resistant dextrin; skin elasticity/hydration with collagen/HA.

==== - RYR → LDL/ApoB: reviews/meta-analyses show ~15–34% LDL-C drops and ApoB reduction. MDPI<ref>{{cite web|title=MDPI|url=https://www.mdpi.com/2072-6643/15/10/2288|publisher=mdpi.com|access-date=2025-11-09}}</ref>PMC<ref>{{cite web|title=PMC|url=https://pmc.ncbi.nlm.nih.gov/articles/PMC6822657/|publisher=pmc.ncbi.nlm.nih.gov|access-date=2025-11-09}}</ref>Frontiers<ref>{{cite web|title=Frontiers|url=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.819482/full|publisher=frontiersin.org|access-date=2025-11-09}}</ref> ====
* Grape seed → BP: controlled-trial meta-analyses report small BP reductions. ScienceDirect<ref>{{cite web|title=ScienceDirect|url=https://www.sciencedirect.com/science/article/abs/pii/S0002822311005876|publisher=sciencedirect.com|access-date=2025-11-09}}</ref>Taylor & Francis Online<ref>{{cite web|title=Taylor & Francis Online|url=https://www.tandfonline.com/doi/full/10.1080/10942912.2021.1901731|publisher=Taylor & Francis Online|access-date=2025-11-09}}</ref>
* Pomegranate → endothelial function: clinical review/meta-analysis indicates improved FMD / inflammatory markers. PubMed<ref>{{cite web|title=PubMed|url=https://pubmed.ncbi.nlm.nih.gov/40296437/|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2025-11-09}}</ref>PMC<ref>{{cite web|title=PMC|url=https://pmc.ncbi.nlm.nih.gov/articles/PMC11875170/|publisher=pmc.ncbi.nlm.nih.gov|access-date=2025-11-09}}</ref>
* Cinnamon → HbA1c/FPG: meta-analyses in T2D show modest improvements (smaller in healthy). BioMed Central<ref>{{cite web|title=BioMed Central|url=https://dmsjournal.biomedcentral.com/articles/10.1186/s13098-023-01057-2|publisher=BioMed Central|access-date=2025-11-09}}</ref>PubMed<ref>{{cite web|title=PubMed|url=https://pubmed.ncbi.nlm.nih.gov/37818728/|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2025-11-09}}</ref>
* K2 (MK-7) → dp-ucMGP / arterial stiffness: RCTs show marked dp-ucMGP decreases in ~12 weeks. ScienceDirect<ref>{{cite web|title=ScienceDirect|url=https://www.sciencedirect.com/science/article/abs/pii/S0021915012006375|publisher=sciencedirect.com|access-date=2025-11-09}}</ref>PubMed<ref>{{cite web|title=PubMed|url=https://pubmed.ncbi.nlm.nih.gov/36695702/|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2025-11-09}}</ref>
* Lutein/zeaxanthin → MPOD: RCTs and reviews show MPOD increases by 8–16 weeks. Nature<ref>{{cite web|title=Nature|url=https://www.nature.com/articles/s41598-020-66962-2|publisher=nature.com|access-date=2025-11-09}}</ref>Advances in Nutrition<ref>{{cite web|title=Advances in Nutrition|url=https://advances.nutrition.org/article/S2161-8313%2822%2900503-8/fulltext|publisher=Advances in Nutrition|access-date=2025-11-09}}</ref>
* CoQ10 → FMD: meta-analysis shows ~+1.45% absolute FMD. PubMed<ref>{{cite web|title=PubMed|url=https://pubmed.ncbi.nlm.nih.gov/38630421/|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2025-11-09}}</ref>
* NR → NAD+: human RCTs: PBMC NAD+ ↑ ~60–140% in weeks. Nature<ref>{{cite web|title=Nature|url=https://www.nature.com/articles/s41467-018-03421-7|publisher=nature.com|access-date=2025-11-09}}</ref>PMC<ref>{{cite web|title=PMC|url=https://pmc.ncbi.nlm.nih.gov/articles/PMC10828186/|publisher=pmc.ncbi.nlm.nih.gov|access-date=2025-11-09}}</ref>
* GSH/NAC → glutathione: oral GSH raises blood/RBC GSH; NAC is a cysteine precursor. Penn State<ref>{{cite web|title=Penn State|url=https://pure.psu.edu/en/publications/randomized-controlled-trial-of-oral-glutathione-supplementation-o|publisher=Penn State|access-date=2025-11-09}}</ref>PMC<ref>{{cite web|title=PMC|url=https://pmc.ncbi.nlm.nih.gov/articles/PMC8234027/|publisher=pmc.ncbi.nlm.nih.gov|access-date=2025-11-09}}</ref>
* Isomaltulose/allulose/resistant dextrin → glycemia/visceral fat: RCTs show lower post-prandial excursions; resistant dextrin reductions in visceral fat over 12 wks. Blueprint Bryan Johnson<ref>{{cite web|title=Blueprint Bryan Johnson|url=https://blueprint.bryanjohnson.com/products/metabolic-protein-powder?srsltid=AfmBOoox9UgCQExQ7r1NuMGYEvvpPUPn3CLPkgAixI9yyTre_B-v5Q-H|publisher=Blueprint Bryan Johnson|access-date=2025-11-09}}</ref>
* Collagen/HA → skin & bone markers: RCTs/meta-analyses show improved skin biophysics; P1NP increases over months.

if you want, I can turn this into a one-page checklist with specific lab codes (Quest/Labcorp equivalents), device recommendations, and a tiny table you can reuse for day-0 vs day-90 logging.