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Openai/6946611c-04ec-800e-a1e4-b37f5f45266c
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===== 15) Depression ===== * Preclinical evidence of CBD's antidepressant-like effects (e.g., Zanelati et al., 2010 and related mechanistic studies) β strong animal data and plausible mechanisms (5-HT1A, BDNF), but human clinical evidence is mixed/limited. BPS Publications<ref>{{cite web|title=BPS Publications|url=https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1476-5381.2009.00521.x|publisher=BPS Publications|access-date=2025-12-24}}</ref> * Large human systematic reviews (2023β2024) β association studies show cannabis use is linked to higher risk of depression in some populations; clinical therapeutic evidence for treating depression with cannabinoids is limited and inconsistent. PMC<ref>{{cite web|title=PMC|url=https://pmc.ncbi.nlm.nih.gov/articles/PMC11035759/|publisher=pmc.ncbi.nlm.nih.gov|access-date=2025-12-24}}</ref>
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