Editing Openai/69585660-954c-8011-b9ec-bc5c70cfea17 (section)

=== Assistant: Here are relevant studies and guideline references that support the ferritin thresholds and clinical practices used for… ===
Here are relevant studies and guideline references that support the ferritin thresholds and clinical practices used for Restless Legs Syndrome (RLS) and iron management:

===== 📚 Clinical Guidelines & Consensus Statements =====
# American Academy of Sleep Medicine (AASM) RLS & PLMD Clinical Practice Guideline (2025) - Recommends iron supplementation (oral or IV) if serum ferritin ≤ 75 ng/mL or transferrin saturation < 20%. - Suggests IV iron if ferritin 75–100 ng/mL. - These are consensus-based recommendations used clinically. PubMed<ref>{{cite web|title=PubMed|url=https://pubmed.ncbi.nlm.nih.gov/39324694/|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2026-01-03}}</ref>
# AASM Iron Target Overview & Thresholds - Iron studies are recommended for all significant RLS cases. - Ferritin intervention cutoff of 75 ng/mL is emphasized, differing from general iron deficiency cutoffs. e-jsm.org<ref>{{cite web|title=e-jsm.org|url=https://www.e-jsm.org/journal/view.php?number=406|publisher=e-jsm.org|access-date=2026-01-03}}</ref>
# Consensus review on iron and RLS (Allen et al., 2018) - Oral iron may be effective for treating RLS in individuals with serum ferritin ≤ 75 µg/L. - IV iron therapies reviewed for severe or refractory cases. ScienceDirect<ref>{{cite web|title=ScienceDirect|url=https://www.sciencedirect.com/science/article/pii/S1389945717315599|publisher=sciencedirect.com|access-date=2026-01-03}}</ref>

===== 🔬 Supportive Research Findings =====
# Schulte et al. (2014): Iron in RLS treatment overview - Reports that low-normal ferritin (< 50 ng/mL) is often associated with more severe RLS and that oral iron benefits those with lower ferritin readings. - This paper cites several smaller studies showing response to iron therapy in RLS with low ferritin. PMC<ref>{{cite web|title=PMC|url=https://pmc.ncbi.nlm.nih.gov/articles/PMC6183309/|publisher=pmc.ncbi.nlm.nih.gov|access-date=2026-01-03}}</ref>
# Wang et al. (2009) – RCT on oral iron for RLS - This randomized, placebo-controlled trial found that oral iron improved RLS symptoms in patients with low-normal ferritin levels compared with placebo, supporting targeting higher ferritin in treatment contexts. PubMed<ref>{{cite web|title=PubMed|url=https://pubmed.ncbi.nlm.nih.gov/19230757/|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2026-01-03}}</ref>
# Li et al. (2023) meta-analysis on low serum ferritin and RLS augmentation - Lower serum ferritin is shown to be associated with RLS augmentation (worsening symptoms due to treatment), supporting the idea that iron status relates to RLS severity. ScienceDirect<ref>{{cite web|title=ScienceDirect|url=https://www.sciencedirect.com/science/article/abs/pii/S1389945723004008|publisher=sciencedirect.com|access-date=2026-01-03}}</ref>

===== 📑 Clinical Threshold Summaries (from guideline literature) =====
* Ferritin ≤ 75 ng/mL: Primary trigger for iron supplementation consideration in adults with RLS → common threshold used in guidelines and consensus. PubMed<ref>{{cite web|title=PubMed|url=https://pubmed.ncbi.nlm.nih.gov/39324694/|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2026-01-03}}</ref>
* Ferritin ≤ 50 ng/mL: Frequently cited intervention cutoff in older data and some clinical contexts. Harvard Health<ref>{{cite web|title=Harvard Health|url=https://www.health.harvard.edu/diseases-and-conditions/are-you-missing-this-simple-treatment-for-restless-legs|publisher=Harvard Health|access-date=2026-01-03}}</ref>
* Ferritin 75–100 ng/mL: Often considered for IV iron if oral therapy is insufficient or poorly absorbed. PubMed<ref>{{cite web|title=PubMed|url=https://pubmed.ncbi.nlm.nih.gov/39324694/|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2026-01-03}}</ref>

===== 📌 Key Takeaway =====

The ferritin levels associated with RLS triggers and treatment targets are not based on a single definitive cutoff from one large trial, but rather:
* Clinical guidelines and consensus group around ≤ 75 ng/mL ferritin as the level at which iron supplementation should be considered in adults with RLS. PubMed<ref>{{cite web|title=PubMed|url=https://pubmed.ncbi.nlm.nih.gov/39324694/|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2026-01-03}}</ref>
* Older supportive data point to lower thresholds (around ≤ 50 ng/mL) also being meaningful. Harvard Health<ref>{{cite web|title=Harvard Health|url=https://www.health.harvard.edu/diseases-and-conditions/are-you-missing-this-simple-treatment-for-restless-legs|publisher=Harvard Health|access-date=2026-01-03}}</ref>
* There is evidence of improved RLS symptoms with iron therapy in patients with low to low-normal ferritin in RCTs and observational studies. PubMed<ref>{{cite web|title=PubMed|url=https://pubmed.ncbi.nlm.nih.gov/19230757/|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2026-01-03}}</ref>

If you want, I can pull specific PDF links to the full text of some of these guideline documents or studies for deeper review.