Editing Openai/69729ae6-bd00-8005-8892-1acd564602bd (section)

===== Comparison of Key Probiotic Colic Products =====

The table below summarizes the main evidence-backed probiotic options for infantile colic, highlighting their composition, study support, formulation, and age suitability:

| Product (Manufacturer)                                                         | Probiotic Strain(s)                                                | Clinical Evidence                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             | Form & Age                                                                                                                                                                                             |
| ------------------------------------------------------------------------------ | ------------------------------------------------------------------ | ------------------------------------------------------------------------------------------------------------------------ | ------------------------------------------------------------------------------------------------------------------------ |
| BioGaia Protectis Baby Drops
BioGaia AB (also sold as Gerber Soothe, Nestlé)   | Limosilactobacillus reuteri DSM 17938                              | • Meta-analysis (4 RCTs) – L. reuteri DSM 17938 significantly improved colic symptoms vs placebo (≈17–25% greater responder rate)
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
. Primarily effective in breastfed infants (recommended by ESPGHAN)
pubmed.ncbi.nlm.nih.gov
link.springer.com
.
• Multiple trials show ~50% reduction in daily crying by week 3 on this probiotic
www1.racgp.org.au
www1.racgp.org.au
. No adverse effects noted.                                                                                                                                           | Oil drops, 5 drops daily (10^8 CFU). Easy to mix into milk or give by spoon. Use from birth – safe in newborns (studied from 1–2 weeks old)
biogaia.com
.                                              |
| Culturelle Baby Digestive Calm + Comfort
DSM /i-Health (Culturelle brand, USA) | Lactobacillus rhamnosus GG + Bifidobacterium animalis BB-12        | • LGG meta-analysis – reduced infant crying by ~32 minutes/day vs placebo; deemed effective for colic in recent analysis
pmc.ncbi.nlm.nih.gov
pmc.ncbi.nlm.nih.gov
.
• BB-12 RCT – 60%+ of colicky infants achieved ≥50% crying reduction on BB-12 (vs ~30% on placebo); significantly fewer crying episodes and more sleep with BB-12
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
.
• Both strains are well-studied and safe in infants; combined use targets digestive balance and has shown colic relief within ~1 week (per manufacturer’s cited studies).                            | Liquid drops, 5 drops daily (contains ~2.5×10^9 CFU total). For 0–12 months (infants). Drops are oral (via spoon or bottle). Start in newborn period as needed for colic, gas, diarrhea, etc.          |
| Culturelle Baby Calm + Colic Drops
DSM /i-Health (Culturelle, Canada)          | Bifidobacterium longum KABP-042 + Pediococcus pentosaceus KABP-041 | • RCT (2024) head-to-head – this dual-strain formula had an 84.6% colic response rate by 2 weeks, outperforming L. reuteri DSM 17938 (59.3% response)
link.springer.com
. Crying duration was significantly lower with the combo at 7, 14, 21 days
link.springer.com
.
• Prior placebo-controlled trials showed this B. longum + Pediococcus mix reduces crying/fussiness within 7–14 days
cdhf.ca
link.springer.com
. Recognized as an effective option for infant colic by pediatric groups (CDHF, etc.).
• No safety issues; well-tolerated like other baby probiotics
link.springer.com
. | Oil drops, 5 drops daily (1×10^9 CFU). Infant drops suitable for newborns (studied from ~2 weeks old). Give via dropper/spoon; shake well. Best for use during colic phase (under ~5–6 months of age). |

Notes: All the above products are probiotic drops designed for infants, making administration easy (no pills or large volumes). It’s important to use them daily for at least 2–3 weeks to assess benefit, as studies typically observed gradual improvement over that periodpubmed.ncbi.nlm.nih.gov<ref>{{cite web|title=pubmed.ncbi.nlm.nih.gov|url=https://pubmed.ncbi.nlm.nih.gov/29279326/#:~:text=Results%3A%20%20Four%20double,fed%20infants|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2026-01-23}}</ref>link.springer.com<ref>{{cite web|title=link.springer.com|url=https://link.springer.com/article/10.1007/s00431-024-05860-5#:~:text=Conclusion%3A%20The%20synbiotic%20tested%20was,natural%20evolution%20of%20infant%20colic|publisher=link.springer.com|access-date=2026-01-23}}</ref>. If one strain/product is not effective after 2–3 weeks, consult a pediatrician – sometimes an alternative strain (or addressing feeding techniques and other causes) may be needed. Always ensure the baby is otherwise healthy (no red-flag symptoms beyond colic) before attributing crying solely to colic and starting probiotic supplementation.