Editing Openai/69729ae6-bd00-8005-8892-1acd564602bd (section)

===== 2. Culturelle Baby Digestive Calm + Comfort Probiotic Drops (i-Health/Culturelle): L. rhamnosus GG + B. animalis BB-12 =====

Strains & Product: Contains Lacticaseibacillus rhamnosus GG (strain ATCC 53103) and Bifidobacterium animalis subsp. lactis BB-12. This liquid supplement (0.29 fl oz bottle) is marketed by Culturelle (DSM/i-Health) to help with colic, gas and fussiness. Each 5-drop dose delivers a clinically studied dose of both probioticsculturelle.com<ref>{{cite web|title=culturelle.com|url=https://culturelle.com/products/digestive-calm-comfort-probiotic-drops?srsltid=AfmBOopNmeHDii62S8VXHohRIuQxjZUF_6eVq4uj1TX5rU7ymp5chc6a#:~:text=best%20choice%3F|publisher=culturelle.com|access-date=2026-01-23}}</ref>. (Culturelle is a leading probiotic brand; LGG and BB-12 are well-known, safe strains in pediatrics.)
Clinical Evidence: L. rhamnosus GG (LGG) – A 2024 meta-analysis of 4 RCTs (168 infants) concluded that LGG significantly reduces daily crying time in colicpmc.ncbi.nlm.nih.gov<ref>{{cite web|title=pmc.ncbi.nlm.nih.gov|url=https://pmc.ncbi.nlm.nih.gov/articles/PMC11384430/#:~:text=Four%20studies%20involving%20168%20infants,one%20study%20reported%20adverse%20events|publisher=pmc.ncbi.nlm.nih.gov|access-date=2026-01-23}}</ref>. Pooled data showed ~33 minutes per day less crying on LGG vs. placebo, along with decreased fecal calprotectin (an inflammation marker)pmc.ncbi.nlm.nih.gov<ref>{{cite web|title=pmc.ncbi.nlm.nih.gov|url=https://pmc.ncbi.nlm.nih.gov/articles/PMC11384430/#:~:text=Four%20studies%20involving%20168%20infants,one%20study%20reported%20adverse%20events|publisher=pmc.ncbi.nlm.nih.gov|access-date=2026-01-23}}</ref>pmc.ncbi.nlm.nih.gov<ref>{{cite web|title=pmc.ncbi.nlm.nih.gov|url=https://pmc.ncbi.nlm.nih.gov/articles/PMC11384430/#:~:text=%3D%E2%88%9232.59%20minutes%3B%2095,one%20study%20reported%20adverse%20events|publisher=pmc.ncbi.nlm.nih.gov|access-date=2026-01-23}}</ref>. The authors found LGG effective for treating infantile colic, noting this is the first probiotic besides L. reuteri with demonstrated benefitpmc.ncbi.nlm.nih.gov<ref>{{cite web|title=pmc.ncbi.nlm.nih.gov|url=https://pmc.ncbi.nlm.nih.gov/articles/PMC11384430/#:~:text=%E2%80%A2%20Lactobacillus%20rhamnosus%20GG%20,reduce%20calprotectin%20content%20in%20stool|publisher=pmc.ncbi.nlm.nih.gov|access-date=2026-01-23}}</ref>. (Earlier smaller trials of LGG had mixed results, but the latest evidence supports its efficacy.) B. animalis BB-12 – A large placebo-controlled trial (192 infants) in 2021 showed BB-12 can significantly soothe colicpubmed.ncbi.nlm.nih.gov<ref>{{cite web|title=pubmed.ncbi.nlm.nih.gov|url=https://pubmed.ncbi.nlm.nih.gov/34550055/#:~:text=and%20immunological%20biomarkers%20were%20evaluated,0.001|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2026-01-23}}</ref>. After 3 weeks of BB-12 (1×10^9 CFU/day), 80% of infants achieved >50% reduction in daily crying, vs ~50% on placebopubmed.ncbi.nlm.nih.gov<ref>{{cite web|title=pubmed.ncbi.nlm.nih.gov|url=https://pubmed.ncbi.nlm.nih.gov/34550055/#:~:text=and%20immunological%20biomarkers%20were%20evaluated,0.001|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2026-01-23}}</ref>pubmed.ncbi.nlm.nih.gov<ref>{{cite web|title=pubmed.ncbi.nlm.nih.gov|url=https://pubmed.ncbi.nlm.nih.gov/34550055/#:~:text=in%20the%20daily%20crying%2Ffussing%20time,group%20compared%20to%20the%20placebo|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2026-01-23}}</ref>. The BB-12 group had fewer daily crying episodes and longer sleep duration than controls (p<0.001)pubmed.ncbi.nlm.nih.gov<ref>{{cite web|title=pubmed.ncbi.nlm.nih.gov|url=https://pubmed.ncbi.nlm.nih.gov/34550055/#:~:text=and%20immunological%20biomarkers%20were%20evaluated,0.001|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2026-01-23}}</ref>. By study end, caregivers of BB-12–treated babies reported better quality-of-life scores, reflecting the easing of infant distresspubmed.ncbi.nlm.nih.gov<ref>{{cite web|title=pubmed.ncbi.nlm.nih.gov|url=https://pubmed.ncbi.nlm.nih.gov/34550055/#:~:text=in%20the%20daily%20crying%2Ffussing%20time,2%2C%20cathelicidin%2C%20slgA%2C%20calprotectin%20and|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2026-01-23}}</ref>pubmed.ncbi.nlm.nih.gov<ref>{{cite web|title=pubmed.ncbi.nlm.nih.gov|url=https://pubmed.ncbi.nlm.nih.gov/34550055/#:~:text=parent%27s%2Fcaregiver%27s%20physical%2C%20emotional%20and%20social,infants%20diagnosed%20with%20infant%20colic|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2026-01-23}}</ref>. No safety concerns were noted. Combined use: While LGG+BB-12 together haven’t been trialed as a unique regimen, the product contains two of the best-supported probiotic strains for infant digestive health and colic relief. Both strains are dairy-free and allergy-friendly in this formulationculturelle.com<ref>{{cite web|title=culturelle.com|url=https://culturelle.com/products/digestive-calm-comfort-probiotic-drops?srsltid=AfmBOopNmeHDii62S8VXHohRIuQxjZUF_6eVq4uj1TX5rU7ymp5chc6a#:~:text=breastfeeding,opened%2C%20use%20within%2060%20days|publisher=culturelle.com|access-date=2026-01-23}}</ref>culturelle.com<ref>{{cite web|title=culturelle.com|url=https://culturelle.com/products/digestive-calm-comfort-probiotic-drops?srsltid=AfmBOopNmeHDii62S8VXHohRIuQxjZUF_6eVq4uj1TX5rU7ymp5chc6a#:~:text=Image%3A%20always%20allergy%20friendly%20%26,GMO|publisher=culturelle.com|access-date=2026-01-23}}</ref>. Many pediatricians consider this multi-strain approach beneficial for broad gut support (LGG predominates in the small intestine; Bifidobacterium in the colon).
Delivery Form: Liquid drops with dropper. Dose is 5 drops once daily (can be given directly by spoon, in a bottle of milk, or while breastfeeding)culturelle.com<ref>{{cite web|title=culturelle.com|url=https://culturelle.com/products/digestive-calm-comfort-probiotic-drops?srsltid=AfmBOopNmeHDii62S8VXHohRIuQxjZUF_6eVq4uj1TX5rU7ymp5chc6a#:~:text=upset%2C%20and%20diarrhea,as%20little%20as%201%20week|publisher=culturelle.com|access-date=2026-01-23}}</ref>culturelle.com<ref>{{cite web|title=culturelle.com|url=https://culturelle.com/products/digestive-calm-comfort-probiotic-drops?srsltid=AfmBOopNmeHDii62S8VXHohRIuQxjZUF_6eVq4uj1TX5rU7ymp5chc6a#:~:text=Image%3A%20directions%20for%200,opened%2C%20use%20within%2060%20days|publisher=culturelle.com|access-date=2026-01-23}}</ref>. The suspension is gluten/dairy-free and requires shaking before use. Once opened, it should be used within ~60 days for full potencyculturelle.com<ref>{{cite web|title=culturelle.com|url=https://culturelle.com/products/digestive-calm-comfort-probiotic-drops?srsltid=AfmBOopNmeHDii62S8VXHohRIuQxjZUF_6eVq4uj1TX5rU7ymp5chc6a#:~:text=upset%2C%20and%20diarrhea,as%20little%20as%201%20week|publisher=culturelle.com|access-date=2026-01-23}}</ref>.
Age Range: Designed for infants 0–12 months. Culturelle labels it for babies “up to 1 year,” and it is safe even for young newborns. Parents are advised to start these drops in early infancy when colic or digestive upset arises. (As always, a pediatrician should confirm severe crying is due to colic and not another issue before starting probiotics.)